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This study uses a functional perspective to examine the reasons young people cite for using psychoactive substances. The study sample comprised young poly-drug users recruited using snowball-sampling methods. Data on lifetime and recent frequency and intensity of use for alcohol, cannabis, amphetamines, ecstasy, LSD and cocaine are presented. A majority of the participants had used at least one of these six drugs to fulfil 11 of 18 measured substance use functions.

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Men are more likely than women to use almost all types of illicit drugs, 13 and illicit drug use is more likely to result in emergency department visits or overdose deaths for men than for women.

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Sex differences and gender are not solely determined by biology, nor are they entirely sociocultural. The interactions among biological, environmental, sociocultural and developmental influences result in phenotypes that may be more masculine or more feminine. These gender-related sex differences in the brain can influence the responses to drugs of abuse, progressive changes in the brain after exposure to drugs of abuse and whether addiction results from drug-taking experiences. The theme of this special issue is sex differences in the brain.

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